Significance of early cellular and molecular changes for the evolution and the prevention of liver cancer

نویسندگان

  • Peter Bannasch
  • Eiman Abdel Aleem
  • P. Bannasch
  • T. Haertel
  • E. A. Aleem
چکیده

In cooperation with: Susanne Brendler-Schwaab, Harald Enzmann, Ludwig Schladt, Toxicology Rodent Studies and Genetic Toxicology, Bayer AG, Wuppertal; Erhard Deml, Doris Oesterle, Institute of Toxicology of the National Research Center for Environment and Health, Neuherberg; Karin Küttler, Werner Mellert, Product Safety Regulations, Toxicology and Ecology, BASF AG, Ludwigshafen; Oliver Mönnikes, Michael Schwarz, Department of Toxicology, Universitiy of Tübingen; Eikichi Okada, Sakae Taira, Department of Gastroenterology, Tokyo Universitiy School of Medicine, Tokyo, Japan; Masao Omata, Department of Pathology, Toyama Medical-Pharmacological University, Toyama, Japan; Ulrike Protzer, Department of Virology (Hygiene Institute), University Hospital, Heidelberg; Kunio Tagegoshi, Tagegoshi Internal Medicine Clinic, Takaoka, Japan; DKFZ: Carina Ittrich, Annette Kopp-Schneider, Central Unit of Biostatistics; Doris Mayer, Research Group Hormones and Signal Transduction; Claus Schröder, Division Virus-Host Interactions; Thomas Flohr, Heinz Werner Thielmann, Division Interaction of Chemicals with Cellular Macromolecules; Andreas Hunzicker, Division Cell Biology.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations

Background: Compared to past decades, humans are exposed to rapidly increasing levels of radiofrequency electromagnetic radiations (RF-EMF). Despite numerous studies, the biological effects of human exposure to different levels of RF-EMF are not fully understood, yet. This study aimed to evaluate the bioeffects of exposure to "900/1800 MHz" and “2.4 GHz" RF-EMFs, and x-rays as well as their pot...

متن کامل

Association between the Asp327Asn Polymorphism of Sex Hormone-Binding Globulin Gene and Prostate Cancer

Background: By binding SHBG hormone to sex hormones, in addition to carrying them in the blood, they regulate the amount of tissue availability. Since the genetic changes in the structure of globulin affect it’s binding to hormones, so in this study the effects of single nucleotide change in exon 8 or rs 6259 in the incidence of prostate cancer is evaluated. Methods: The study populati...

متن کامل

Performance of methylation and expression fluctuations of sonic hedgehog genes in gastric adenocarcinoma

Gastric cancer (GC) is considered as one of the most serious cancers, and in Iran, due to environmental factors in different regions, it has a high frequency. Apart from environmental factors, genetic and epigenetic ones also play a key role in the development of carcinogenesis of GC. In this regard, the study of functioning of the molecular mechanisms involved in the carcinogenesis and also tu...

متن کامل

Bacterial and tissue biomarkers of gastric cancer: new findings and future perspectives: review article

Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. It has been proposed that the specific genotypes of Helicobacter pylori (H. pylori) are the causative agents in the development of gastroduodenal diseases, such as chronic atrophic gastritis, peptic ulcerations, and GC. However, disease progression to GC occurs in only a small proportion of infected patients. Re...

متن کامل

A Review of Mitochondrial Biogenesis and Cellular Response

Abstract Background and Objectives Mitochondrial biogenesis is a complex process involving the coordinated expression of mitochondrial and nuclear genes, the import of the products of the latter into the organelle and turnover of this process. Mitochondrial malfunction or defects in any of the many pathways involved in mitochondrial biogenesis can lead to degenerative diseases and possibly pla...

متن کامل

The significance of gene profiling in diagnosis the cause of drug resistance in cancer

Chemoresistance is one of the main obstacles to the success of cancer treatment and one of the most important causes of death in patients. In the last decade, progress in high-throughput technologies, including microarray, sequencing, and bioinformatics has greatly resulted in cancer gene profiling and identification of biomarkers for cancer prognosis and prediction. This has greatly improved t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2003